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Index > Protein center > Lfng(Gene name) > Mouse
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  • Lfng (Gene name),
  • Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (Protein name ),  LFNG_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Lfng;
    Protein name:
    Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe;
    Alternative:
    O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules inhibiting Jagged mediated Notch signaling. Essential mediator of somite segmentation and patterning. During somite boundary formation, it restricts Notch activity in the presomitic mesoderm to a boundary-formig territory in the posterior half of the prospective somite. In this region, Notch function activates a set of genes that are involved in boundary formation and in anterior-posterior somite identity. Ectopically expressed in the thymus, Lfgn inhibits Notch signaling which results in inhibition of T-cell commitment and promotes B-cell development in lymphoid progenitors. May play a role in boundary formation of the enamel knot.
    Subcellular Location:
    Golgi apparatus membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    378
    Sequence:
    50:
    MLQRCGRRLL | LALVGALLAC | LLVLTADPPP | TPMPAERGRR | ALRSLAGSSG | 
    100:
    GAPASGSRAA | VDPGVLTREV | HSLSEYFSLL | TRARRDADPP | PGVASRQGDG | 
    150:
    HPRPPAEVLS | PRDVFIAVKT | TRKFHRARLD | LLFETWISRH | KEMTFIFTDG | 
    200:
    EDEALAKLTG | NVVLTNCSSA | HSRQALSCKM | AVEYDRFIES | GKKWFCHVDD | 
    250:
    DNYVNLRALL | RLLASYPHTQ | DVYIGKPSLD | RPIQATERIS | EHKVRPVHFW | 
    300:
    FATGGAGFCI | SRGLALKMGP | WASGGHFMST | AERIRLPDDC | TIGYIVEALL | 
    350:
    GVPLIRSGLF | HSHLENLQQV | PTTELHEQVT | LSYGMFENKR | NAVHIKGPFS | 
    378:
    VEADPSRFRS | VHCHLYPDTP | WCPRSAIF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    E15413h
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    96T
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    ELISA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    E15413r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    E15413m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    E15413c
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    Packing:
    96T
    ELISA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    E15413b
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    Packing:
    96T
    CLIA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    U15413c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    U15413r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    U15413m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    U15413h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    U15413b
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Polyclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Polyclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    P15413Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    P15413Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Cat.:
    P15413Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Monoclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Monoclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Monoclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Monoclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Protein for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Protein for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Protein for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Protein for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Protein for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway."
      Johnston S.H. , Rauskolb C. , Wilson R. , Prabhakaran B. , Irvine K.D. , Vogt T.F.
      Development124:2245-2254(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila."
      Cohen B. , Bashirullah A. , Dagnino L. , Campbell C. , Fisher W.W. , Leow C.C. , Whiting E. , Ryan D. , Zinyk D. , Boulianne G. , Hui C.-C. , Gallie B. , Phillips R.A. , Lipshitz H.D. , Egan S.E.
      Nat. Genet.16:283-288(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis."
      Cole S.E. , Levorse J.M. , Tilghman S.M. , Vogt T.F.
      Dev. Cell3:75-84(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-143;DEVELOPMENTAL STAGE
      strain: 129S6/SvEvTac.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Bone marrow.
      tissue: Lung.
    5. 5.
      "Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse."
      del Barco Barrantes I. , Elia A.J. , Wuensch K. , De Angelis M.H. , Mak T.W. , Rossant J. , Conlon R.A. , Gossler A. , de la Pompa J.L.
      Curr. Biol.9:470-480(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    6. 6.
      "Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth."
      Mustonen T. , Tuemmers M. , Mikami T. , Itoh N. , Zhang N. , Gridley T. , Thesleff I.
      Dev. Biol.248:281-293(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    7. 7.
      "Lunatic fringe is an essential mediator of somite segmentation and patterning."
      Evrard Y.A. , Lun Y. , Aulehla A. , Gan L. , Johnson R.L.
      Nature394:377-381(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
    8. 8.
      "Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes."
      Moran J.L. , Johnston S.H. , Rauskolb C. , Bhalerao J. , Bowcock A.M. , Vogt T.F.
      Mamm. Genome10:535-541(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
    9. 9.
      "Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1."
      Koch U. , Lacombe T.A. , Holland D. , Bowman J.L. , Cohen B.L. , Egan S.E. , Guidos C.J.
      Immunity15:225-236(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    10. 10.
      "Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling."
      Morales A.V. , Yasuda Y. , Ish-Horowicz D.
      Dev. Cell3:63-74(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
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